Uses of SGT-67 in chemical research

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SGT-67 is a recently introduced type of research chemicals with high potential in terms of study applications. Belonging to the group of synthetic cannabinoids, it is reported to exhibit many of the characteristics and properties common for this category of compounds. Unlike steroids and hormones, which may be of natural origin, SGT-67 is a purely artificial chemical created in lab environments from different precursors. 

As a new substance on the market, it requires further in-depth studies and careful use. It is important to remember that human consumption may be harmful until the opposite has been confirmed. At the moment, the research chemical should only be used for forensic and research purposes.

Structure

The formal IUPAC name for the chemical is 1-(5-fluoropentyl)-n-(2-phenylpropane-2-yl)-1h-indole-3-carboxamide. It belongs to the group of indole-3-carboxamides, which makes it a synthetic cannabinoid. The chemical formula is c23h27fn2o, and the molecular mass is 366.02. The compound is often referred to as 5F-cumyl-pica. 

Other chemicals of this kind include 5F-APICA (also known as STS-135). SGT-67 (5F-CUMYL-PICA) is its an analog. The key structural difference between the two is the replacement of the N-adamantyl group with an N-cumyl group in the new molecule. 

Effects

The chemical is believed to act like an agonist with regard to cannabinoid receptors. These receptors, which are found throughout the human body, are included in the endocannabinoid system. The latter contributes to a number of different physiological processes, including memory, mood, the sensation of pain, and appetite.

Available studies

To date, few studies have been conducted on the effects of SGT-67. Here are two known examples. Their findings need to be replicated in further research.

One study on SGT-67 proved its nature as an agonist activating cannabinoid receptors in the human body. The second known study was focused on exploring the metabolism of subjects, along with the clearance of the chemical. Both rat and human liver microsomes and hepatocytes were used. The former are membrane fragments coming from homogenized liver, while the latter includes liver cells collected from the collagenase-perfused liver. These were used for comparison with urine samples and in vivo rat plasma. 

The study concluded that the chemical is associated with fast metabolic clearance based on the incubation with the microsomes. It should be noted that metabolism in vivo took longer, which explained the detection of the compound in the rat plasma. Hypothermia was also examined in the study, and SGT-67 showed hypothermic effects with identification of 28 metabolites. 

Word of caution Laboratories that wish to conduct scientific studies involving SGT-67 should make sure they receive the compound from a research chemical manufacturer that guarantees its purity. It is essential to follow basic measures in terms of safe handling and shelf life extension. Many synthetic substances, including cannabinoids and stimulants (Benzodiazepines and others) are associated with high abuse potential. The chemical must never be self-administered or used without supervision from qualified specialists.

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