Lysergic Acid Amides: What Do We Know About Them?
Due to the widespread use of Lysergic acid amides for recreational purposes, as well as due to the public resonance caused by government projects, lysergic acid diethylamide has long been on the list of banned drugs. That is why it’s pharmacodynamics, as well as the effect on brain activity, are not fully understood, although the first data appeared due to Hofmann’s research. However, Research chemicals become more widespread. The scientists studied the crystal structure of the substance in combination with the receptors, conducted experiments on model organisms, and, having received special permission, gave small doses to volunteers.
How It Works
Lysergic acid is a structural analog of the neurotransmitter serotonin, which plays an essential role in the work of the reward system of the brain. Once in the body, acid affects various G-protein-related receptors: dopamine (for example, LSD is known to act like a D2 receptor agonist), serotonin, and adrenoreceptors, which react to adrenaline and noradrenaline. Acid is illegal in most countries, but it is possible to buy research chemicals online.
Even though the biochemical properties of the drug have not yet been studied in any detail, studies show that the serotonin 5-HT2B receptor is the main target of Lysergic acid. In particular, such receptor effects of LSD were demonstrated by two independent groups of scientists from Switzerland. During experiments with 5-HT2B and its homologous 5-HT2A receptor, scientists discovered that under the influence of LSD, one of the extracellular loops of the serotonin receptor forms a lid, trapping the substance molecule in its active center. This causes the substance to be continuously activated and thus causes hallucinations. It is known that it is possible to buy research chemicals China on the Internet.
In 2016, British scientists were the first to succeed in obtaining the use of LSD in a placebo-controlled fMRI study by the Neural correlates of the LSD experience revealed by multimodal neuroimaging. Participants from the active experimental group took 0.75 milligrams of the substance. The tomography data showed that after the administration of LSD in the brain, increased activation of the network of the passive mode of the brain is observed, as well as a general decrease in the orderliness of work.
Areas that usually work separately started working together. Therefore, the primary visual cortex was activated synchronously with other areas. The scientists suggested that this mechanism of the brain’s functioning is the basis for the appearance of hallucinations. It is noteworthy that the official organizations refused to give the researchers money to experiment. They collected the necessary amount (about 25,000 pounds) by launching a public crowdfunding campaign.
Lysergic Acid Amides in the Future
It can be said that in recent years, interest in research of mental effects of LSD has increased. For the first time since the middle of the last century, scientists have been exploring its impact on speech and emotions. Nevertheless, scientists are still planning to start studying the phenomenon of human consciousness. And research chemicals for sale will help.